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| China Open | ||
| Surface: Hard | Date: Sep. 29 - Oct. 7 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Tennys Sandgren | Win | 7-5, 6-3 |
| Second Round | Dusan Lajovic | Loss | 4-6, 6-2, 4-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 27 - Sep. 9 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Stan Wawrinka | Loss | 3-6, 2-6, 5-7 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 12 - Aug. 19 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mischa Zverev | Win | 7-6 (7-5), 7-5 |
| Third Round | Novak Djokovic | Loss | 6-2, 3-6, 4-6 |
| Rogers Cup presented by National Bank | ||
| Surface: Hard | Date: Aug. 6 - Aug. 12 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Fernando Verdasco | Win | 4-6, 6-2, 7-6 (7-5) |
| Third Round | Frances Tiafoe | Win | 7-6 (7-1), 3-6, 7-6 (7-4) |
| Quarterfinals | Kevin Anderson | Loss | 2-6, 2-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 2 - Jul. 15 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Stan Wawrinka | Loss | 6-1, 6-7 (3-7), 6-7 (5-7), 4-6 |
| Fever-Tree Championships | ||
| Surface: Grass | Date: Jun. 18 - Jun. 24 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Damir Dzumhur | Win | 6-3, 6-7 (4-7), 6-3 |
| Second Round | Novak Djokovic | Loss | 4-6, 1-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 27 - Jun. 10 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Mohamed Safwat | Win | 6-1, 6-4, 7-6 (7-1) |
| Second Round | Jared Donaldson | Win | 6-7 (2-7), 6-4, 4-6, 6-4, 10-8 |
| Third Round | Fernando Verdasco | Loss | 6-7 (4-7), 2-6, 4-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 13 - May 20 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Kei Nishikori | Loss | 7-6 (7-4), 5-7, 4-6 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 5 - May 13 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Milos Raonic | Loss | 5-7, 6-3, 3-6 |
| Barcelona Open Banco Sabadell | ||
| Surface: Clay | Date: Apr. 23 - Apr. 29 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Gilles Simon | Win | 6-2, 6-1 |
| Third Round | Malek Jaziri | Win | 7-5, 3-6, 7-6 (10-8) |
| Quarterfinals | Pablo Carreno Busta | Loss | 3-6, 6-7 (4-7) |
| Monte-Carlo Rolex Masters | ||
| Surface: Clay | Date: Apr. 15 - Apr. 22 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Pierre-Hugues Herbert | Win | 3-6, 6-2, 6-4 |
| Third Round | Philipp Kohlschreiber | Win | 4-6, 6-3, 6-4 |
| Quarterfinals | David Goffin | Win | 6-4, 7-6 (7-5) |
| Semifinals | Rafael Nadal | Loss | 4-6, 1-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 20 - Apr. 1 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Maximilian Marterer | Win | 4-6, 6-2, 6-1 |
| Third Round | Jeremy Chardy | Loss | 4-6, 4-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 7 - Mar. 18 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Fernando Verdasco | Loss | 6-7 (4-7), 6-4, 3-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 26 - Mar. 3 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Malek Jaziri | Loss | 6-4, 5-7, 4-6 |
| ABN AMRO World Tennis Tournament | ||
| Surface: Hard | Date: Feb. 12 - Feb. 18 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Yuichi Sugita | Win | 6-4, 7-6 (7-5) |
| Second Round | Filip Krajinovic | Win | 7-6 (7-4), 7-5 |
| Quarterfinals | Andrey Rublev | Win | 6-3, 6-4 |
| Semifinals | David Goffin | Win | 6-3, 0-1 Retired |
| Final | Roger Federer | Loss | 2-6, 2-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 28 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Dennis Novak | Win | 6-3, 6-2, 6-1 |
| Second Round | Mackenzie McDonald | Win | 4-6, 6-2, 6-4, 0-6, 8-6 |
| Third Round | Andrey Rublev | Win | 6-3, 4-6, 6-4, 6-4 |
| Fourth Round | Nick Kyrgios | Win | 7-6 (7-3), 7-6 (7-4), 4-6, 7-6(7-4) |
| Quarterfinals | Kyle Edmund | Loss | 4-6, 6-3, 3-6, 4-6 |
| Brisbane International presented by Suncorp | ||
| Surface: Hard | Date: Dec. 31 - Jan. 7 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | John Millman | Win | 4-6, 7-6 (10-8), 6-3 |
| Quarterfinals | Kyle Edmund | Win | 6-3, 6-7 (3-7), 6-4 |
| Semifinals | Nick Kyrgios | Loss | 6-3, 1-6, 4-6 |
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