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| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Laslo Djere | Win | 6-1, 3-6, 6-3, 6-4 |
| Second Round | Corentin Moutet | Win | 6-4, 6-2, 3-6, 6-3 |
| Third Round | Lorenzo Sonego | Loss | 7-5, 6-0, 3-6, 6-7 (5-7), 3-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 10 - May 21 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alex Molcan | Win | 6-3, 6-4 |
| Third Round | Alejandro Davidovich Fokina | Win | 7-6 (10-8), 6-3 |
| Fourth Round | Yannick Hanfmann | Loss | 6-7 (5-7), 6-4, 3-6 |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 26 - May 7 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Stan Wawrinka | Win | 7-5, 6-4 |
| Third Round | Yoshihito Nishioka | Win | 6-2, 7-5 |
| Fourth Round | Karen Khachanov | Loss | 6-7 (8-10), 4-6 |
| Banja Luka Open | ||
| Surface: Clay | Date: Apr. 17 - Apr. 23 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Juan Pablo Varillas | Win | 6-2, 6-2 |
| Quarterfinals | Damir Dzumhur | Win | 7-5, 6-3 |
| Semifinals | Alex Molcan | Win | 6-2, 6-4 |
| Final | Dusan Lajovic | Loss | 3-6, 6-4, 4-6 |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 9 - Apr. 16 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jaume Munar | Win | 4-6, 6-2, 6-2 |
| Third Round | Karen Khachanov | Win | 7-6 (7-4), 6-2 |
| Quarterfinals | Jan-Lennard Struff | Win | 6-1, 7-6 (7-5) |
| Semifinals | Taylor Fritz | Win | 5-7, 6-1, 6-3 |
| Final | Holger Rune | Win | 5-7, 6-2, 7-5 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 2 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | J.J. Wolf | Win | 7-6 (7-3), 6-4 |
| Third Round | Miomir Kecmanovic | Win | 6-1, 6-2 |
| Fourth Round | Jannik Sinner | Loss | 2-6, 4-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 19 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jiri Lehecka | Win | 6-4, 6-2 |
| Third Round | Ugo Humbert | Win | 7-5, 6-3 |
| Fourth Round | Cameron Norrie | Loss | 2-6, 4-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 27 - Mar. 4 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Filip Krajinovic | Win | 7-5, 6-2 |
| Second Round | Alejandro Davidovich Fokina | Win | 1-6, 7-6 (8-6), 7-6 (7-3) |
| Quarterfinals | Botic Van De Zandschulp | Win | 6-3, 7-6 (7-3) |
| Semifinals | Alexander Zverev | Win | 6-3, 7-6 (11-9) |
| Final | Daniil Medvedev | Loss | 2-6, 2-6 |
| Qatar ExxonMobil Open | ||
| Surface: Hard | Date: Feb. 20 - Feb. 25 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Tallon Griekspoor | Win | 1-6, 6-1, 7-6 (8-6) |
| Quarterfinals | Jiri Lehecka | Loss | 6-4, 4-6, 3-6 |
| ABN Amro World Tennis Tournament | ||
| Surface: Hard | Date: Feb. 13 - Feb. 19 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Alex De Minaur | Loss | 4-6, 4-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Dominic Thiem | Win | |
| Second Round | Emil Ruusuvuori | Win | |
| Third Round | Daniel Evans | Win | |
| Fourth Round | Holger Rune | Win | |
| Quarterfinals | Novak Djokovic | Loss |
| Adelaide International 2 | ||
| Surface: Hard | Date: Jan. 9 - Jan. 14 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Thanasi Kokkinakis | Loss |
| Adelaide International 1 | ||
| Surface: Hard | Date: Jan. 1 - Jan. 8 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Roberto Bautista Agut | Loss |
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