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| BNP Paribas Open | ||
| Surface: Hard | Date: Oct. 6 - Oct. 17 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mackenzie McDonald | Win | 6-4, 6-2 |
| Third Round | Filip Krajinovic | Win | 6-2, 7-6 (7-1) |
| Fourth Round | Grigor Dimitrov | Loss | 6-4, 4-6, 3-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 30 - Sep. 12 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Richard Gasquet | Win | 6-4, 6-3, 6-1 |
| Second Round | Dominik Koepfer | Win | 6-4, 6-1, 6-2 |
| Third Round | Pablo Andujar | Win | 6-0, 6-4, 6-3 |
| Fourth Round | Daniel Evans | Win | 6-3, 6-4, 6-3 |
| Quarterfinals | Botic van de Zandschulp | Win | 6-3, 6-0, 4-6, 7-5 |
| Semifinals | Felix Auger-Aliassime | Win | 6-4, 7-5, 6-2 |
| Final | Novak Djokovic | Win | 6-4, 6-4, 6-4 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 15 - Aug. 22 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mackenzie McDonald | Win | 6-2, 6-2 |
| Third Round | Grigor Dimitrov | Win | 6-3, 6-3 |
| Quarterfinals | Pablo Carreno Busta | Win | 6-1, 6-1 |
| Semifinals | Andrey Rublev | Loss | 6-2, 3-6, 3-6 |
| Open de la Banque Nationale presentee par Rogers | ||
| Surface: Hard | Date: Aug. 9 - Aug. 15 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alexander Bublik | Win | 4-6, 6-3, 6-4 |
| Third Round | James Duckworth | Win | 6-2, 6-4 |
| Quarterfinals | Hubert Hurkacz | Win | 2-6, 7-6 (8-6), 7-6 (7-5) |
| Semifinals | John Isner | Win | 6-2, 6-2 |
| Final | Reilly Opelka | Win | 6-4, 6-3 |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 28 - Jul. 11 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Jan-Lennard Struff | Win | 6-4, 6-1, 4-6, 7-6(7-3) |
| Second Round | Carlos Alcaraz | Win | 6-4, 6-1, 6-2 |
| Third Round | Marin Cilic | Win | 6-7 (3-7), 3-6, 6-3, 6-3, 6-2 |
| Fourth Round | Hubert Hurkacz | Loss | 6-2, 6-7 (2-7), 6-3, 3-6, 3-6 |
| Mallorca Championships | ||
| Surface: Grass | Date: Jun. 20 - Jun. 26 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Corentin Moutet | Win | 6-4, 6-2 |
| Quarterfinals | Casper Ruud | Win | 7-5, 6-1 |
| Semifinals | Pablo Carreno Busta | Win | 3-6, 6-3, 6-2 |
| Final | Sam Querrey | Win | 6-4, 6-2 |
| NOVENTI OPEN | ||
| Surface: Grass | Date: Jun. 14 - Jun. 20 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Jan-Lennard Struff | Loss | 6-7 (6-8), 3-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 30 - Jun. 13 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Alexander Bublik | Win | 6-3, 6-3, 7-5 |
| Second Round | Tommy Paul | Win | 3-6, 6-1, 6-4, 6-3 |
| Third Round | Reilly Opelka | Win | 6-4, 6-2, 6-4 |
| Fourth Round | Cristian Garin | Win | 6-2, 6-1, 7-5 |
| Quarterfinals | Stefanos Tsitsipas | Loss | 3-6, 6-7 (3-7), 5-7 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 9 - May 16 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Aslan Karatsev | Loss | 2-6, 4-6 |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 29 - May 9 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alejandro Davidovich Fokina | Win | 4-6, 6-4, 6-2 |
| Third Round | Cristian Garin | Loss | 4-6, 7-6 (7-2), 1-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 23 - Apr. 4 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Yen-Hsun Lu | Win | 6-2, 6-2 |
| Third Round | Alexei Popyrin | Win | 7-6 (7-3), 6-7 (7-9), 6-4 |
| Fourth Round | Frances Tiafoe | Win | 6-4, 6-3 |
| Quarterfinals | Roberto Bautista Agut | Loss | 4-6, 2-6 |
| Open 13 Provence | ||
| Surface: Hard | Date: Mar. 8 - Mar. 14 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Egor Gerasimov | Win | 6-2, 6-4 |
| Quarterfinals | Jannik Sinner | Win | 6-2, 6-4 |
| Semifinals | Matthew Ebden | Win | 6-4, 3-0 Retired |
| Final | Pierre-Hugues Herbert | Win | 6-4, 6-7 (4-7), 6-4 |
| ABN AMRO World Tennis Tournament | ||
| Surface: Hard | Date: Mar. 1 - Mar. 7 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Dusan Lajovic | Loss | 6-7 (4-7), 4-6 |
| Australian Open | ||
| Surface: Hard | Date: Feb. 8 - Feb. 21 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Vasek Pospisil | Win | 6-2, 6-2, 6-4 |
| Second Round | Roberto Carballes Baena | Win | 6-2, 7-5, 6-1 |
| Third Round | Filip Krajinovic | Win | 6-3, 6-3, 4-6, 3-6, 6-0 |
| Fourth Round | Mackenzie McDonald | Win | 6-4, 6-2, 6-3 |
| Quarterfinals | Andrey Rublev | Win | 7-5, 6-3, 6-2 |
| Semifinals | Stefanos Tsitsipas | Win | 6-4, 6-2, 7-5 |
| Final | Novak Djokovic | Loss | 5-7, 2-6, 2-6 |
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