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| Roland Garros | ||
| Surface: Red Clay | Date: May 22 - Jun. 5 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Facundo Bagnis |
| Gonet Geneva Open | ||
| Surface: Clay | Date: May 15 - May 21 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Richard Gasquet | Loss | 2-6, 6-7 (5-7) |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 3 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Andy Murray | Win | 6-4, 6-2 |
| Third Round | Pedro Martinez | Win | 6-3, 6-4 |
| Fourth Round | Jenson Brooksby | Win | 7-5, 6-1 |
| Quarterfinals | Hubert Hurkacz | Loss | 6-7 (7-9), 3-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 20 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Tomas Machac | Win | 6-3, 6-2 |
| Third Round | Gael Monfils | Loss | 6-4, 3-6, 1-6 |
| Abierto Mexicano Telcel presentado por HSBC | ||
| Surface: Hard | Date: Feb. 21 - Feb. 26 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Benoit Paire | Win | 6-3, 6-4 |
| Second Round | Pablo Andujar | Win | 6-1, 6-2 |
| Quarterfinals | Yoshihito Nishioka | Win | 6-2, 6-3 |
| Semifinals | Rafael Nadal | Loss | 3-6, 3-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 17 - Jan. 30 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Henri Laaksonen | Win | 6-1, 6-4, 7-6 (7-3) |
| Second Round | Nick Kyrgios | Win | 7-6 (7-1), 6-4, 4-6, 6-2 |
| Third Round | Botic van de Zandschulp | Win | 6-4, 6-4, 6-2 |
| Fourth Round | Maxime Cressy | Win | 6-2, 7-6 (7-4), 6-7 (4-7), 7-5 |
| Quarterfinals | Felix Auger-Aliassime | Win | 6-7 (4-7), 3-6, 7-6 (7-2), 7-5, 6-4 |
| Semifinals | Stefanos Tsitsipas | Win | 7-6 (7-5), 4-6, 6-4, 6-1 |
| Final | Rafael Nadal | Loss | 6-2, 7-6 (7-5), 4-6, 4-6, 5-7 |
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