| ||||||||||||||
| BNP Paribas Open | ||
| Surface: Hard | Date: Oct. 6 - Oct. 17 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Petra Martic | Win | 6-1, 6-3 |
| Third Round | Veronika Kudermetova | Win | 6-1, 6-0 |
| Fourth Round | Jelena Ostapenko | Loss | 4-6, 3-6 |
| J&T Banka Ostrava Open 2021 | ||
| Surface: Hard | Date: Sep. 20 - Sep. 26 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Yulia Putintseva | Win | 6-4, 6-4 |
| Quarterfinals | Elena Rybakina | Win | 7-6 (7-5), 6-2 |
| Semifinals | Maria Sakkari | Loss | 4-6, 5-7 |
| US Open | ||
| Surface: Hard | Date: Aug. 30 - Sep. 12 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Jamie Loeb | Win | 6-3, 6-4 |
| Second Round | Fiona Ferro | Win | 3-6, 7-6 (7-3), 6-0 |
| Third Round | Anett Kontaveit | Win | 6-3, 4-6, 6-3 |
| Fourth Round | Belinda Bencic | Loss | 6-7 (12-14), 3-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 15 - Aug. 22 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ons Jabeur | Loss | 3-6, 3-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 28 - Jul. 11 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Su-Wei Hsieh | Win | 6-4, 6-4 |
| Second Round | Vera Zvonareva | Win | 6-1, 6-3 |
| Third Round | Irina-Camelia Begu | Win | 6-1, 6-0 |
| Fourth Round | Ons Jabeur | Loss | 7-5, 1-6, 1-6 |
| Nature Valley International | ||
| Surface: Grass | Date: Jun. 21 - Jun. 26 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Heather Watson | Win | 6-3, 6-7 (4-7), 7-5 |
| Second Round | Daria Kasatkina | Loss | 6-4, 0-6, 1-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 30 - Jun. 13 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Kaja Juvan | Win | 6-0, 7-5 |
| Second Round | Rebecca Peterson | Win | 6-1, 6-1 |
| Third Round | Anett Kontaveit | Win | 7-6 (7-4), 6-0 |
| Fourth Round | Marta Kostyuk | Win | 6-3, 6-4 |
| Quarterfinals | Maria Sakkari | Loss | 4-6, 4-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 9 - May 16 | Seed: 15 |
| Round | Opponent | W / L | Result |
| First Round | Alison Riske | Win | 5-4 Retired |
| Second Round | Madison Keys | Win | 7-5, 6-1 |
| Third Round | Barbora Krejcikova | Win | 3-6, 7-6 (7-5), 7-5 |
| Quarterfinals | Elina Svitolina | Win | 6-2, 7-5 |
| Semifinals | Cori Gauff | Win | 7-6 (7-3), 6-3 |
| Final | Karolina Pliskova | Win | 6-0, 6-0 |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 29 - May 9 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Alison Riske | Win | 6-1, 6-1 |
| Second Round | Laura Siegemund | Win | 6-3, 6-3 |
| Third Round | Ashleigh Barty | Loss | 5-7, 4-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 23 - Apr. 4 | Seed: 15 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Barbora Krejcikova | Win | 6-4, 6-2 |
| Third Round | Ana Konjuh | Loss | 4-6, 6-2, 2-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Mar. 7 - Mar. 13 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Misaki Doi | Win | 6-2, 6-4 |
| Third Round | Garbine Muguruza | Loss | 0-6, 4-6 |
| Adelaide International | ||
| Surface: Hard | Date: Feb. 22 - Feb. 27 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Madison Brengle | Win | 6-3, 6-4 |
| Second Round | Maddison Inglis | Win | 6-1, 6-3 |
| Quarterfinals | Danielle Collins | Win | 6-2, 3-0 Retired |
| Semifinals | Jil Teichmann | Win | 6-3, 6-2 |
| Final | Belinda Bencic | Win | 6-2, 6-2 |
| Australian Open | ||
| Surface: Hard | Date: Feb. 8 - Feb. 21 | Seed: 15 |
| Round | Opponent | W / L | Result |
| First Round | Arantxa Rus | Win | 6-1, 6-3 |
| Second Round | Camila Giorgi | Win | 6-2, 6-4 |
| Third Round | Fiona Ferro | Win | 6-4, 6-3 |
| Fourth Round | Simona Halep | Loss | 6-3, 1-6, 4-6 |
| Gippsland Trophy | ||
| Surface: Hard | Date: Jan. 31 - Feb. 6 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Kaja Juvan | Win | 2-6, 6-2, 6-1 |
| Third Round | Ekaterina Alexandrova | Loss | 4-6, 2-6 |
© 2021 by STATS PERFORM.Any commercial use or distribution without the express written consent of STATS PERFORM is strictly prohibited.