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| US Open | ||
| Surface: Hard | Date: Aug. 29 - Sep. 11 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Jasmine Paolini | Win | 6-3, 6-0 |
| Second Round | Sloane Stephens | Win | 6-3, 6-2 |
| Third Round | Lauren Davis | Win | 6-3, 6-4 |
| Fourth Round | Jule Niemeier | Win | 2-6, 6-4, 6-0 |
| Quarterfinals | Jessica Pegula | Win | 6-3, 7-6 (7-4) |
| Semifinals | Aryna Sabalenka | Win | 3-6, 6-1, 6-4 |
| Final | Ons Jabeur | Win | 6-2, 7-6 (7-5) |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 14 - Aug. 21 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Sloane Stephens | Win | |
| Third Round | Madison Keys | Loss |
| National Bank Open presented by Rogers | ||
| Surface: Hard | Date: Aug. 8 - Aug. 14 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ajla Tomljanovic | Win | |
| Third Round | Beatriz Haddad Maia | Loss |
| BNP Paribas Poland Open | ||
| Surface: Clay | Date: Jul. 25 - Jul. 31 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Magdalena Frech | Win | |
| Second Round | Gabriela Lee | Win | |
| Quarterfinals | Caroline Garcia | Loss |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 27 - Jul. 10 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Jana Fett | Win | |
| Second Round | Lesley Pattinama Kerkhove | Win | |
| Third Round | Alize Cornet | Loss |
| Roland Garros | ||
| Surface: Red Clay | Date: May 22 - Jun. 5 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Lesia Tsurenko | Win | |
| Second Round | Alison Riske | Win | |
| Third Round | Danka Kovinic | Win | |
| Fourth Round | Qinwen Zheng | Win | |
| Quarterfinals | Jessica Pegula | Win | |
| Semifinals | Daria Kasatkina | Win | |
| Final | Coco Gauff | Win |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 8 - May 15 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Elena-Gabriela Ruse | Win | |
| Third Round | Victoria Azarenka | Win | |
| Quarterfinals | Bianca Andreescu | Win | |
| Semifinals | Aryna Sabalenka | Win | |
| Final | Ons Jabeur | Win |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 18 - Apr. 24 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Eva Lys | Win | |
| Quarterfinals | Emma Raducanu | Win | |
| Semifinals | Liudmila Samsonova | Win | |
| Final | Aryna Sabalenka | Win |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 3 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Viktorija Golubic | Win | |
| Third Round | Madison Brengle | Win | |
| Fourth Round | Cori Gauff | Win | |
| Quarterfinals | Petra Kvitova | Win | |
| Semifinals | Jessica Pegula | Win | |
| Final | Naomi Osaka | Win |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 20 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Anhelina Kalinina | Win | |
| Third Round | Clara Tauson | Win | |
| Fourth Round | Angelique Kerber | Win | |
| Quarterfinals | Madison Keys | Win | |
| Semifinals | Simona Halep | Win | |
| Final | Maria Sakkari | Win |
| Qatar TotalEnergies Open | ||
| Surface: Hard | Date: Feb. 20 - Feb. 26 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Viktorija Golubic | Win | |
| Third Round | Daria Kasatkina | Win | |
| Quarterfinals | Aryna Sabalenka | Win | |
| Semifinals | Maria Sakkari | Win | |
| Final | Anett Kontaveit | Win |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 14 - Feb. 19 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Daria Kasatkina | Win | |
| Second Round | Jelena Ostapenko | Loss |
| Australian Open | ||
| Surface: Hard | Date: Jan. 17 - Jan. 30 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Harriet Dart | Win | |
| Second Round | Rebecca Peterson | Win | |
| Third Round | Daria Kasatkina | Win | |
| Fourth Round | Sorana Cirstea | Win | |
| Quarterfinals | Kaia Kanepi | Win | |
| Semifinals | Danielle Collins | Loss |
| Adelaide International 1 | ||
| Surface: Hard | Date: Jan. 3 - Jan. 9 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Daria Saville | Win | |
| Second Round | Leylah Fernandez | Win | |
| Quarterfinals | Victoria Azarenka | Win | |
| Semifinals | Ashleigh Barty | Loss |
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