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| US Open | ||
| Surface: Hard | Date: Aug. 29 - Sep. 11 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Madison Brengle | Win | 7-5, 6-2 |
| Second Round | Elizabeth Mandlik | Win | 7-5, 6-2 |
| Third Round | Shelby Rogers | Win | 4-6, 6-4, 6-3 |
| Fourth Round | Veronika Kudermetova | Win | 7-6 (7-1), 6-4 |
| Quarterfinals | Ajla Tomljanovic | Win | 6-4, 7-6 (7-4) |
| Semifinals | Caroline Garcia | Win | 6-1, 6-3 |
| Final | Iga Swiatek | Loss | 2-6, 6-7 (5-7) |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 14 - Aug. 21 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Catherine McNally | Win | |
| Third Round | Petra Kvitova | Loss |
| National Bank Open presented by Rogers | ||
| Surface: Hard | Date: Aug. 8 - Aug. 14 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Qinwen Zheng | Loss |
| Mubadala Silicon Valley Classic | ||
| Surface: Hard | Date: Aug. 1 - Aug. 7 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Madison Keys | Win | |
| Quarterfinals | Veronika Kudermetova | Loss |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 27 - Jul. 10 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Mirjam Bjorklund | Win | |
| Second Round | Katarzyna Kawa | Win | |
| Third Round | Diane Parry | Win | |
| Fourth Round | Elise Mertens | Win | |
| Quarterfinals | Marie Bouzkova | Win | |
| Semifinals | Tatjana Maria | Win | |
| Final | Elena Rybakina | Loss |
| bett1open | ||
| Surface: Grass | Date: Jun. 13 - Jun. 19 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Karolina Muchova | Win | |
| Second Round | Alycia Parks | Win | |
| Quarterfinals | Aliaksandra Sasnovich | Win | |
| Semifinals | Coco Gauff | Win | |
| Final | Belinda Bencic | Loss |
| Roland Garros | ||
| Surface: Red Clay | Date: May 22 - Jun. 5 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Magda Linette | Loss |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 8 - May 15 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Sorana Cirstea | Win | |
| Second Round | Ajla Tomljanovic | Win | |
| Third Round | Yulia Putintseva | Win | |
| Quarterfinals | Maria Sakkari | Win | |
| Semifinals | Daria Kasatkina | Win | |
| Final | Iga Swiatek | Loss |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 28 - May 8 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Jasmine Paolini | Win | |
| Second Round | Varvara Gracheva | Win | |
| Third Round | Belinda Bencic | Win | |
| Quarterfinals | Simona Halep | Win | |
| Semifinals | Ekaterina Alexandrova | Win | |
| Final | Jessica Pegula | Win |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 18 - Apr. 24 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Marketa Vondrousova | Win | |
| Second Round | Daria Kasatkina | Win | |
| Quarterfinals | Paula Badosa | Loss |
| Credit One Charleston Open | ||
| Surface: Green Clay | Date: Apr. 4 - Apr. 10 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Emma Navarro | Win | |
| Third Round | Irina-Camelia Begu | Win | |
| Quarterfinals | Anhelina Kalinina | Win | |
| Semifinals | Amanda Anisimova | Win | |
| Final | Belinda Bencic | Loss |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 3 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Magda Linette | Win | |
| Third Round | Kaia Kanepi | Win | |
| Fourth Round | Danielle Collins | Loss |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 20 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Daria Saville | Loss |
| Qatar TotalEnergies Open | ||
| Surface: Hard | Date: Feb. 20 - Feb. 26 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Aliaksandra Sasnovich | Win | |
| Third Round | Tereza Martincova | Win | |
| Quarterfinals | Anett Kontaveit | Loss |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 14 - Feb. 19 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Vera Zvonareva | Win | |
| Second Round | Jessica Pegula | Win | |
| Quarterfinals | Simona Halep | Loss |
| Sydney Tennis Classic | ||
| Surface: Hard | Date: Jan. 10 - Jan. 15 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Astra Sharma | Win | |
| Second Round | Petra Kvitova | Win | |
| Quarterfinals | Anett Kontaveit | Loss |
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