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| BNP Paribas WTA Finals Shenzhen | ||
| Surface: Hard | Date: Oct. 27 - Nov. 3 | Seed: 3 |
| Round | Opponent | W / L | Result |
| Round Robin | Petra Kvitova | Win | 7-6 (7-1), 4-6, 6-4 |
| China Open | ||
| Surface: Hard | Date: Sep. 28 - Oct. 6 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Jessica Pegula | Win | 6-3, 7-6 (7-5) |
| Second Round | Andrea Petkovic | Win | 6-2, 6-0 |
| Third Round | Alison Riske | Win | 6-4, 6-0 |
| Quarterfinals | Bianca Andreescu | Win | 5-7, 6-3, 6-4 |
| Semifinals | Caroline Wozniacki | Win | 6-4, 6-2 |
| Final | Ashleigh Barty | Win | 3-6, 6-3, 6-2 |
| Toray Pan Pacific Open | ||
| Surface: Decoturf | Date: Sep. 16 - Sep. 22 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Viktoriya Tomova | Win | 7-5, 6-3 |
| Quarterfinals | Yulia Putintseva | Win | 6-4, 6-4 |
| Semifinals | Elise Mertens | Win | 6-4, 6-1 |
| Final | Anastasia Pavlyuchenkova | Win | 6-2, 6-3 |
| US Open | ||
| Surface: Hard | Date: Aug. 26 - Sep. 8 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Anna Blinkova | Win | 6-4, 6-7 (5-7), 6-2 |
| Second Round | Magda Linette | Win | 6-2, 6-4 |
| Third Round | Cori Gauff | Win | 6-3, 6-0 |
| Fourth Round | Belinda Bencic | Loss | 5-7, 4-6 |
| Western & Southern Womens Open | ||
| Surface: Hard | Date: Aug. 11 - Aug. 18 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Aliaksandra Sasnovich | Win | 7-6 (7-3), 2-6, 6-2 |
| Third Round | Su-Wei Hsieh | Win | 7-6 (7-3), 5-7, 6-2 |
| Quarterfinals | Sofia Kenin | Loss | 4-6, 6-1, 0-2 Retired |
| Rogers Cup presented by National Bank | ||
| Surface: Hard | Date: Aug. 5 - Aug. 11 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Tatjana Maria | Win | 6-2, 0-0 Retired |
| Third Round | Iga Swiatek | Win | 7-6 (7-4), 6-4 |
| Quarterfinals | Serena Williams | Loss | 3-6, 4-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 1 - Jul. 14 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Yulia Putintseva | Loss | 6-7 (4-7), 2-6 |
| Nature Valley Classic | ||
| Surface: Grass | Date: Jun. 17 - Jun. 23 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Maria Sakkari | Win | 6-1, 4-6, 6-3 |
| Second Round | Yulia Putintseva | Loss | 2-6, 3-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 26 - Jun. 9 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Anna Karolina Schmiedlova | Win | 0-6, 7-6 (7-4), 6-1 |
| Second Round | Victoria Azarenka | Win | 4-6, 7-5, 6-3 |
| Third Round | Katerina Siniakova | Loss | 4-6, 2-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 12 - May 19 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Dominika Cibulkova | Win | 6-3, 6-3 |
| Third Round | Mihaela Buzarnescu | Win | 6-3, 6-3 |
| Quarterfinals | Kiki Bertens | Loss | Retired |
| Mutua Madrid Open | ||
| Surface: Hard | Date: May 4 - May 12 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Dominika Cibulkova | Win | 6-2, 7-6 (8-6) |
| Second Round | Sara Sorribes Tormo | Win | 7-6 (7-5), 3-6, 6-0 |
| Third Round | Aliaksandra Sasnovich | Win | 6-2, 6-3 |
| Quarterfinals | Belinda Bencic | Loss | 6-3, 2-6, 5-7 |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 22 - Apr. 28 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Su-Wei Hsieh | Win | 6-4, 6-3 |
| Quarterfinals | Donna Vekic | Win | 6-3, 4-6, 7-6 (7-4) |
| Semifinals | Anett Kontaveit | Loss | Retired |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 19 - Mar. 31 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Yanina Wickmayer | Win | 6-0, 6-7 (3-7), 6-1 |
| Third Round | Su-Wei Hsieh | Loss | 6-4, 6-7 (4-7), 3-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 6 - Mar. 17 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Kristina Mladenovic | Win | 6-3, 6-4 |
| Third Round | Danielle Collins | Win | 6-4, 6-2 |
| Fourth Round | Belinda Bencic | Loss | 3-6, 1-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 17 - Feb. 23 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Kristina Mladenovic | Loss | 3-6, 3-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 14 - Jan. 27 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Magda Linette | Win | 6-4, 6-2 |
| Second Round | Tamara Zidansek | Win | 6-2, 6-4 |
| Third Round | Su-Wei Hsieh | Win | 5-7, 6-4, 6-1 |
| Fourth Round | Anastasija Sevastova | Win | 4-6, 6-3, 6-4 |
| Quarterfinals | Elina Svitolina | Win | 6-4, 6-1 |
| Semifinals | Karolina Pliskova | Win | 6-2, 4-6, 6-4 |
| Final | Petra Kvitova | Win | 7-6 (7-2), 5-7, 6-4 |
| Brisbane International presented by Suncorp | ||
| Surface: Hard | Date: Dec. 31 - Jan. 6 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Destanee Aiava | Win | 6-3, 6-2 |
| Quarterfinals | Anastasija Sevastova | Win | 3-6, 6-0, 6-4 |
| Semifinals | Lesia Tsurenko | Loss | 2-6, 4-6 |
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