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| Zhengzhou Open | ||
| Surface: Hard | Date: Sep. 9 - Sep. 15 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jelena Ostapenko | Win | 6-1, 6-2 |
| Quarterfinals | Petra Martic | Loss | 5-7, 7-5, 4-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 26 - Sep. 8 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Victoria Azarenka | Win | 3-6, 6-3, 6-4 |
| Second Round | Yulia Putintseva | Loss | 3-6, 6-7 (3-7) |
| Western & Southern Womens Open | ||
| Surface: Hard | Date: Aug. 11 - Aug. 18 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Petra Martic | Win | 6-1, 6-4 |
| Second Round | Saisai Zheng | Win | 6-4, 6-3 |
| Third Round | Maria Sakkari | Loss | 7-6 (7-4), 4-6, 4-6 |
| Rogers Cup presented by National Bank | ||
| Surface: Hard | Date: Aug. 5 - Aug. 11 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Anastasia Pavlyuchenkova | Loss | 6-3, 3-6, 5-7 |
| Mubadala Silicon Valley Classic | ||
| Surface: Hard | Date: Jul. 29 - Aug. 4 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Coco Vandeweghe | Win | 6-3, 6-3 |
| Quarterfinals | Carla Suarez Navarro | Win | 3-6, 6-2, 6-4 |
| Semifinals | Donna Vekic | Win | 6-4, 6-3 |
| Final | Saisai Zheng | Loss | 3-6, 6-7 (3-7) |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 1 - Jul. 14 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Magdalena Rybarikova | Loss | 2-6, 4-6 |
| Nature Valley International | ||
| Surface: Grass | Date: Jun. 23 - Jun. 29 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Tamara Zidansek | Win | 6-2, 6-3 |
| Third Round | Caroline Wozniacki | Win | 2-6, 6-4, 7-6 (7-5) |
| Quarterfinals | Kiki Bertens | Loss | 4-6, 6-3, 4-6 |
| Nature Valley Classic | ||
| Surface: Grass | Date: Jun. 17 - Jun. 23 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Su-Wei Hsieh | Loss | 3-6, 6-2, 6-7 (1-7) |
| Libema Open | ||
| Surface: Grass | Date: Jun. 10 - Jun. 16 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Destanee Aiava | Loss | 6-7 (3-7), 6-1, 4-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 26 - Jun. 9 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Dominika Cibulkova | Win | 7-5, 6-1 |
| Second Round | Amanda Anisimova | Loss | 4-6, 2-6 |
| Internationaux de Strasbourg | ||
| Surface: Clay | Date: May 19 - May 25 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Lin Zhu | Win | 6-0, 6-1 |
| Second Round | Laura Siegemund | Win | 6-4, 6-3 |
| Quarterfinals | Monica Puig | Win | 6-1, 3-6, 6-2 |
| Semifinals | Dayana Yastremska | Loss | 4-6, 4-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 12 - May 19 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Alize Cornet | Loss | 1-6, 4-6 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 4 - May 12 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Svetlana Kuznetsova | Loss | 5-7, 4-6 |
| Volvo Car Open | ||
| Surface: Green Clay | Date: Apr. 1 - Apr. 7 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Kateryna Kozlova | Win | 3-6, 6-3, 6-3 |
| Third Round | Monica Puig | Loss | 2-6, 5-7 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 19 - Mar. 31 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ajla Tomljanovic | Loss | 3-6, 4-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 6 - Mar. 17 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ajla Tomljanovic | Win | 6-3, 4-6, 6-0 |
| Third Round | Lesia Tsurenko | Win | 6-2, 7-5 |
| Fourth Round | Angelique Kerber | Loss | 1-6, 6-4, 4-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 17 - Feb. 23 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ivana Jorovic | Win | 6-4, 6-0 |
| Third Round | Belinda Bencic | Loss | 4-6, 6-2, 6-7 (7-9) |
| St. Petersburg Ladies Trophy | ||
| Surface: Hard | Date: Jan. 28 - Feb. 3 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alison Van Uytvanck | Win | 6-1, 6-4 |
| Quarterfinals | Ekaterina Alexandrova | Win | 6-3, 6-4 |
| Semifinals | Kiki Bertens | Loss | 6-7 (5-7), 2-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 14 - Jan. 27 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Anna Kalinskaya | Win | 6-1, 6-4 |
| Second Round | Katie Boulter | Win | 6-3, 6-4 |
| Third Round | Amanda Anisimova | Loss | 3-6, 2-6 |
| Sydney International | ||
| Surface: Hard | Date: Jan. 6 - Jan. 12 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Petra Kvitova | Loss | 1-6, 5-7 |
| Shenzhen Gemdale Open | ||
| Surface: Hard | Date: Dec. 31 - Jan. 5 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Tatjana Maria | Win | 3-6, 6-3, 6-1 |
| Second Round | Ekaterina Alexandrova | Win | 6-3, 6-3 |
| Quarterfinals | Maria Sharapova | Win | 6-1, 4-2 Retired |
| Semifinals | Yafan Wang | Win | 6-2, 6-1 |
| Final | Alison Riske | Win | 4-6, 7-6 (7-2), 6-3 |
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