| ||||||||||||||
| Roland Garros | ||
| Surface: Red Clay | Date: May 22 - Jun. 5 | Seed: 17 |
| Round | Opponent | W / L | Result |
| First Round | Filip Krajinovic | Loss | 6-7 (5-7), 2-6, 3-6 |
| Gonet Geneva Open | ||
| Surface: Clay | Date: May 15 - May 21 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Christopher O'Connell | Win | 6-3, 7-5 |
| Quarterfinals | Tallon Griekspoor | Win | 6-4, 3-6, 6-3 |
| Semifinals | Casper Ruud | Loss | 6-7 (2-7), 5-7 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 8 - May 15 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Stan Wawrinka | Loss | 6-3, 5-7, 2-6 |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 28 - May 8 | Seed: 15 |
| Round | Opponent | W / L | Result |
| First Round | Sebastian Korda | Loss | 3-6, 5-7 |
| BMW Open by American Express | ||
| Surface: Red Clay | Date: Apr. 25 - May 1 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Oscar Otte | Loss | 6-7 (4-7), 2-6 |
| Fayez Sarofim & Co. US Men's Clay Court Championship | ||
| Surface: Clay | Date: Apr. 4 - Apr. 10 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mitchell Krueger | Win | 3-6, 6-2, 6-4 |
| Quarterfinals | Gijs Brouwer | Win | 6-3, 7-5 |
| Semifinals | Nick Kyrgios | Win | 6-3, 7-5 |
| Final | John Isner | Win | 6-3, 7-6 (9-7) |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 3 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Francisco Cerundolo | Loss | 1-6, 1-3 Retired |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 20 | Seed: 17 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Lorenzo Musetti | Win | 6-1, 6-4 |
| Third Round | Denis Shapovalov | Win | 6-7 (4-7), 6-4, 6-4 |
| Fourth Round | Rafael Nadal | Loss | 6-7 (3-7), 6-7 (5-7) |
| Delray Beach Open by VITACOST.com | ||
| Surface: Hard | Date: Feb. 14 - Feb. 20 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jack Sock | Win | 6-7 (6-8), 7-6 (7-4), 6-1 |
| Quarterfinals | Adrian Mannarino | Win | 7-6 (7-2), 3-6, 6-1 |
| Semifinals | John Millman | Win | 7-6 (10-8), 6-7 (3-7), 7-6 (7-4) |
| Final | Cameron Norrie | Loss | 6-7 (1-7), 6-7 (4-7) |
| Dallas Open | ||
| Surface: Hard | Date: Feb. 7 - Feb. 13 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Cedrik-Marcel Stebe | Win | 7-6 (7-3), 7-6 (10-8) |
| Quarterfinals | Adrian Mannarino | Win | 6-3, 6-4 |
| Semifinals | John Isner | Win | 7-6 (9-7), 7-6 (24-22) |
| Final | Jenson Brooksby | Win | 7-6 (7-5), 7-6 (7-3) |
| Australian Open | ||
| Surface: Hard | Date: Jan. 17 - Jan. 30 | Seed: 23 |
| Round | Opponent | W / L | Result |
| First Round | Kevin Anderson | Win | 6-3, 6-4, 7-6 (7-3) |
| Second Round | Dominik Koepfer | Win | 6-4, 6-3, 7-6 (7-4) |
| Third Round | Denis Shapovalov | Loss | 6-7 (4-7), 6-4, 3-6, 4-6 |
| Sydney Tennis Classic | ||
| Surface: Hard | Date: Jan. 10 - Jan. 15 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jordan Thompson | Win | 6-3, 6-2 |
| Quarterfinals | Brandon Nakashima | Win | 7-6 (7-4), 6-2 |
| Semifinals | Andy Murray | Loss | 7-6 (8-6), 4-6, 4-6 |
| Melbourne Summer Set 1 | ||
| Surface: Hard | Date: Jan. 4 - Jan. 9 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Maxime Cressy | Loss | 6-4, 6-7 (5-7), 6-7 (9-11) |
© 2022 by STATS PERFORM.Any commercial use or distribution without the express written consent of STATS PERFORM is strictly prohibited.